An endogenous ‘hypertensive factor’ enhances the voltage‐dependent calcium current

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Abstract
The effects of an immunoaffinity‐purified putative endogenous hypertensive factor (HF) on voltage‐dependent calcium current in frog cardiac myocytes were assessed. In 9 out of 10 cells, HF reversibly increased the peak amplitude of the calcium current. HF increased peak calcium current density at −5 mV from a control level of 1.8 ± 1.3 pA/pF (mean ± SD) to 4.4 ± 2.0 pA/pF. HF shifted the peak of the calcium current‐voltage relationship in the hyperpolarizing direction. HF shifted the voltage dependence of the inactivation of the calcium current to more negative potentials with prepulses from −80 to 0 mV, but the inactivation was not affected with prepulses more positive than 0 mV. Modulation of the voltage‐dependent calcium current by HF may be the mechanism underlying its pressor effects.

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