The role of 15-lipoxygenase in atherogenesis: pro- and antiatherogenic actions
- 1 April 1997
- journal article
- review article
- Published by Wolters Kluwer Health in Current Opinion in Lipidology
- Vol. 8 (2) , 111-117
- https://doi.org/10.1097/00041433-199704000-00009
Abstract
Oxidative modification converts LDL to an atherogenic form and 15-lipoxygenase has been implicated in this process. Several lines of experimental evidence support such a proatherogenic action of the enzyme. However, recent data obtained with transgenic rabbits overexpressing 15-lipoxygenase suggest also an antiatherogenic effect. In this paper the pathophysiological relevance of 15-lipoxygenase in atherogenesis is critically reviewed.Keywords
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