The estimation of fetal haemoglobin in healthy adults by radioimmunoassay

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Abstract
A radioimmunoassay (RIA) for the measurement of fetal Hb (HbF) was established and used to determine the distribution of HbF in 2463 British adults between the ages of 18 and 65 yr. Although a range in HbF values was similar in both genders a shift towards higher values is seen in females, and the mean HbF% is higher in females at all ages between 18 and 55 yr. A significant and different fall in HbF over the age range studied was noted between females (47%) and males (23%). The difference in mean HbF between the genders was less marked after age 40 yr and a small rise in HbF production was measured in females of ages 50-54 yr.