Uterine proteins and the activation of embryos from mice during delayed implantation

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Abstract
Ovariectomy-induced delay of implantation was used to study the role of the uterine environment in controlling implantation in mice. Labeling studies in vivo showed that uterine protein synthesis and secretion was maximal 2-5 h and 24-30 h after the estradiol injection which initiated implantation. Embryos removed from uteri 5, 12 or 30 h after estradiol injection were able to transport and utilize precursors of nucleic acids and proteins in short-term cultures at the same rate as normal embryos, although delayed embryos had low levels of activity. Delayed embryos were metabolically activated within 5 h of release from delay, perhaps because of the hormonally-induced changes in uterine proteins which occurred at this time.

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