Evolution of Shape Complementarity and Catalytic Efficiency from a Primordial Antibody Template
- 17 December 1999
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 286 (5448) , 2345-2348
- https://doi.org/10.1126/science.286.5448.2345
Abstract
The crystal structure of an efficient Diels-Alder antibody catalyst at 1.9 angstrom resolution reveals almost perfect shape complementarity with its transition state analog. Comparison with highly related progesterone and Diels-Alderase antibodies that arose from the same primordial germ line template shows the relatively subtle mutational steps that were able to evolve both structural complementarity and catalytic efficiency.Keywords
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