Paradoxical Retention of Uric Acid by Uricosuric Drugs in Low Dosage.

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Abstract
Salicylate, phenylbutazone, certain phenylbutazone derivatives and probenecid, all of which in high plasma drug concentrations increase the uric acid clearance, are shown by appropriate renal clearance techniques to depress the uric acid clearance at low plasma drug concentrations. Significance of this paradoxical reversibility of effects is discussed in relation to controversial aspects of phenylbutazone uricosuria, the phenomenon of "compensatory" uric acid retention after discontinuance of uricosuric agents, and the nature of tubular transport mechanisms for uric acid.