Anti-staphylococcal activity of temafloxacin, ciprofloxacin, ofloxacin and enoxacin
- 1 November 1991
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 28 (5) , 695-699
- https://doi.org/10.1093/jac/28.5.695
Abstract
Four fluoroquinolones were tested for antimicrobial activity against 300 isolates of staphylococci collected from medical centres throughout the United States. No cross-resistance to methidllin or oxacillin and the fluoroquinolones was observed. All four drugs were bactericidal agents and all ciprofloxacin-susceptible strains were inhibited at recommended breakpoint concentrations. Ciprofloxacin-resistant strains showed complete cross-resistance to the other fluoroquinolones. The relative potency of the study drugs as judged by MIC/MBC determinations was: temaflox-acin > ciprofloxacin > ofloxacin > enoxacin.Keywords
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