The biochemistry of aromatic amines. 9. Mercapturic acids as metabolites of aniline and 2-naphthylamine

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Abstract
A substance was detected in the urine of rats, rabbits and guinea pigs dosed with 2-naphthylamine which yields 2-acetamido-6-naphthol and a mercapturic acid when acidified with mineral acid, and which is probably N-acetyl-S-(2-acetamido-5,6-dihydro-6-hydroxy-5-naphthyl)-L-cysteine. (2-Amino-l-naphthyl)mercapturic acid was detected in the urine of dogs and rats dosed with 2-naphthylamine. This mercapturic acid is not excreted as an acid-labile precursor. Possible differences in the mode of origin of these 2 mercapturic acids are discussed. o-and p-Aminophenyl- and p-acetamidophenyl-mercapturic acids were detected in the urine of rats and rabbits dosed with aniline.