Course of Diabetes and Development of Cataracts After Injecting Dehydroascorbic Acid and Related Substances
- 31 March 1951
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 165 (1) , 61-65
- https://doi.org/10.1152/ajplegacy.1951.165.1.61
Abstract
Dehydroascorbic, dehydroisoascorbic and dehydroglucoascorbic acids all produce hyperglycemia in rats that persists with little change over a period of 28 weeks. The animals also have polyuria, glycosuria, polyphagia and polydipsia. They fail to gain wt. normally. This establishes a diagnosis of permanent diabetes. Cataracts occur after a period of weeks. The relationship between hyperglycemia and the time required for the appearance of mature cataracts is described by the equation (x - 5.7) (y - 225) = 1276 where x and y represent the time in weeks and the blood sugar in mg./100 cc. of blood respectively.Keywords
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