EXPOSURE TO CARBON-MONOXIDE OR TO NICOTINE DOES NOT INHIBIT-PGI2 FORMATION BY RAT ARTERIAL RINGS INCUBATED WITH HUMAN PLATELET-RICH PLASMA
- 1 January 1982
- journal article
- research article
- Vol. 10 (6) , 412-419
Abstract
The effects of nicotine and CO on the production of PGI2 by rat arterial rings were studied. For PGI2 analysis, a bioassay based on platelet-rich plasma aggregation with ADP was used. Neither nicotine in the incubate nor pretreatment with CO decreased PGI2 production as detectable in this bioassay system. Neither had a direct effect on the ADP-induced aggregability of human platelet-rich plasma. Consequently, these agents do not seem to be responsible for the temporary increase in platelet aggregability after cigarette smoking. [The involvement of smoking in atherosclerosis is discussed].This publication has 3 references indexed in Scilit:
- Demonstration of PGl2 production by isolated perfused rat lungs with platelet aggregation testProstaglandins, 1980
- Differences in biological activity of arachidonic acid in perfused lungs from guinea pig, rat and manEuropean Journal of Pharmacology, 1980
- Some effects of nicotine on plateletsThrombosis Research, 1975