Gene expression profiles of mouse spermatogenesis during recovery from irradiation
Open Access
- 19 November 2009
- journal article
- Published by Springer Nature in Reproductive Biology and Endocrinology
- Vol. 7 (1) , 130
- https://doi.org/10.1186/1477-7827-7-130
Abstract
Irradiation or chemotherapy that suspend normal spermatogenesis is commonly used to treat various cancers. Fortunately, spermatogenesis in many cases can be restored after such treatments but knowledge is limited about the re-initiation process. Earlier studies have described the cellular changes that happen during recovery from irradiation by means of histology. We have earlier generated gene expression profiles during induction of spermatogenesis in mouse postnatal developing testes and found a correlation between profiles and the expressing cell types. The aim of the present work was to utilize the link between expression profile and cell types to follow the cellular changes that occur during post-irradiation recovery of spermatogenesis in order to describe recovery by means of gene expression.Keywords
This publication has 40 references indexed in Scilit:
- Changes in Gene Expression in Somatic Cells of Rat Testes Resulting from Hormonal Modulation and Radiation-Induced Germ Cell Depletion1Biology of Reproduction, 2010
- Estrogen Enhances Recovery From Radiation‐Induced Spermatogonial Arrest in Rat TestesJournal of Andrology, 2009
- Restricted expression of the human DAZ protein in premeiotic germ cellsHuman Reproduction, 2008
- The radiation‐induced block in spermatogonial differentiation is due to damage to the somatic environment, not the germ cellsJournal of Cellular Physiology, 2006
- Analysis of Cell-Type-Specific Gene Expression During Mouse Spermatogenesis1Biology of Reproduction, 2004
- X-irradiation-induced changes in the progression of type B spermatogonia and preleptotene spermatocytesMolecular Reproduction and Development, 2000
- A study by in situ hybridization of the stage of appearance and disappearance of the transition protein 2 and the mitochondrial capsule seleno‐protein mrnas during spermatogenesis in the mouseMolecular Reproduction and Development, 1992
- Biosynthesis and localization of lactate dehydrogenase X in pachytene spermatocytes and spermatids of mouse testesDevelopmental Biology, 1977
- Dissociation of the mouse testis and characterization of isolated spermatogenic cells.Journal of Histochemistry & Cytochemistry, 1977
- Gamma-ray sensitivity of spermatogonia of the mouseJournal of Experimental Zoology, 1957