Production of monoclonal antibodies by hybridoma cells in a flat sheet membrane bioreactor
- 1 May 1990
- journal article
- research article
- Published by Wiley in Biotechnology Progress
- Vol. 6 (3) , 220-224
- https://doi.org/10.1021/bp00003a011
Abstract
The purpose of this study was to investigate hybridoma growth and monoclonal antibody formation in a flat sheet membrane bioreactor. The effects of several different molecular weight cutoff membranes on growth and antibody formation were investigated. Nutrient and toxic product diffusion through the membranes were quantified, and the kinetic and physical constants of the system were determined.This publication has 0 references indexed in Scilit: