ANTIGEN PROVOCATION TO THE SKIN, NOSE AND LUNG, IN CHILDREN WITH ASTHMA - IMMEDIATE AND DUAL HYPERSENSITIVITY REACTIONS

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  • 1 January 1982
    • journal article
    • research article
    • Vol. 47  (3) , 587-594
Abstract
Most (18/21) children with perennial asthma gave dual (immediate and late) responses to bronchial provocation with 2 of Dermatophagoides pteronyssinus, and either timothy grass pollen or cat fur. Most (19/21) also showed dual responses to skin prick tests, only half (11/21) gave dual responses in the nose, mainly with timothy grass pollen, and these were associated with allergic rhinitis. Only 2 children gave dual responses in lung, skin and nose to both antigens, and only 2 gave immediate reactions without late reactions in all positive tests; most showed different patterns of response according to the organ tested or the antigen used for provocation. Local factors may be important in determining the pattern of allergic response in a target organ, and dual responses apparently are strongly associated with the patient''s symptoms.