Acute Renal Failure

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Abstract
PathophysiologyAnuriaThe pattern of anuria followed by an eventual diuretic period and recovery of function has a striking similarity regardless of the variety of factors entering into the pathogenesis of acute renal failure. Pathological changes, as described in Oliver's microdissection studies,118 consist of two distinctive tubular lesions. When a nephrotoxin produces renal failure a large segment of proximal tubule shows a uniform cellular necrosis down to, but not including, the basement membrane. When ischemia is associated with renal failure there is a complete disruption of tubular continuity, including dissolution of the basement membrane, with secondary ingrowth of Connective-Tissue elements. . . .