Enantioselective Determination of Mianserin and Its Desmethyl Metabolite in Plasma During Treatment of Depressed Japanese Patients

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Abstract
A method for the analysis of the enantiomers of mianserin and its main metabolite desmethylmianserin in plasma using a chiral AGP high performance liquid chromatography column is described. In the majority of 66 depressed Japanese patients, the concentration of the more active S(+)-mianserin was higher than that of the R(-)-enantiomer. The mean S/R ratio was 1.9 ± 0.9 (SD) (range 0.5–4.8). The concentration of S(+)- varied between 19 and 223 nM, while that of the R(-)-mianserin varied between 14 and 72 nM. Among 42 of the 66 plasma samples in which the enantiomers of desmethylmi-anserin could be measured, the R-form predominated in all but one. S-Desm-ethylmianserin was in most of the samples present in concentrations of

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