INFLUENCE OF VITAMIN C ON THE ANTIHISTAMINE ACTION OF VARIOUS DRUGS: EFFECT ON BRONCHIOLAR REACTIONS TO EPHEDRINE, EPINEPHRINE, BENZEDRINE AND CALCIUM, AS STUDIED BY MICROSCOPIC OBSERVATION

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Abstract
The use of experimental methods in establishing the physiologic properties of the therapeutic agents commonly employed in the respiratory tract has been given an effective impetus through the work of Proetz1 on ciliary action of the nasal mucosa. The microscopic observation of bronchiolar reactions opens up an additional experimental method for evaluation of the effect of drugs on the lower respiratory tract. Outstanding among the problems of rhinology is that of the circulation. The constant play between vasodilatation and vasoconstriction directs a large part of present therapeutic efforts. This is particularly important for the drugs that are commonly used in the upper respiratory tract, such as ephedrine, epinephrine, benzedrine and calcium. Do these drugs which constrict the nasal mucosa increase or diminish bronchiolar size? Are the various salts of these compounds of equal activity, and what effect, if any, does vitamin C have on them? These were some of