PHYSICOCHEMICAL STUDIES ON PRECIPITATING AND NON-PRECIPITATING ANTIBODIES AFTER PRIMARY IMMUNIZATION

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Abstract
Antisera were obtained from rabbits within 30 days (early antisera) and 90–120 days (late antisera) after the last of a series of intravenous injections of serum protein antigens (primary response). The antibodies present in early antisera were found capable of precipitating with the antigen and of agglutinating sensitized red blood cells, whereas those present in late antisera exhibited only the latter property. These two types of antibodies could not be differentiated on the basis of their electrophoretic, sedimentation, and salting out properties. Both behaved essentially as gamma globulins.