In vitro interactions of Caenorhabditis elegans dystrophin with dystrobrevin and syntrophin
- 8 November 1999
- journal article
- Published by Wiley in FEBS Letters
- Vol. 461 (1-2) , 59-62
- https://doi.org/10.1016/s0014-5793(99)01421-0
Abstract
Dystrophin, the product of the gene mutated in Duchenne muscular dystrophy (DMD) is bound by its C-terminus to a protein complex including the related protein dystrobrevin. Both proteins contain a putative coiled-coil domain consisting of two α-helices. It has been reported that the two proteins bind to each other by the first one of the two α-helices. We have revisited this question using the Caenorhabditis elegans homologs of dystrophin and dystrobrevin. In vitro interaction occurs through the more conserved second helix. We propose a new model of dystrophin interactions with associated proteins.Keywords
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