Prostaglandin and Nerve-Mediated Response of the Rabbit Eye to Argon Laser Irradiation of the Iris
- 1 January 1977
- journal article
- research article
- Published by S. Karger AG in Ophthalmologica
- Vol. 175 (3) , 153-158
- https://doi.org/10.1159/000308648
Abstract
Irradiation of the pigmented rabbit iris with a moderately low dose of Ar laser light (5 applications of 750 mW, 500 .mu.m, 0.5 s) caused an immediate ocular response consisting of mitosis, a rise of intraocular pressure and is accompanied by a disruption of the blood-aqueous barrier. Prostaglandin-like material was present in the aqueous humour withdrawn 60 min after irradiation. Prior treatment with indomethacin i.v. (20 mg/kg) or benoxinate topically (Novesine; 0.4%) greatly reduced the response, and combined use of the 2 drugs virtually abolished the ocular changes.Keywords
This publication has 1 reference indexed in Scilit:
- Prostaglandin influences on intraocular pressure and pupil sizeAmerican Journal of Physiology-Legacy Content, 1967