MACROGLOBULINEMIA: REPORT OF TWO CASES
- 1 May 1958
- journal article
- research article
- Published by American College of Physicians in Annals of Internal Medicine
- Vol. 48 (5) , 1055-1069
- https://doi.org/10.7326/0003-4819-48-5-1055
Abstract
One of the two patients is surviving. Following treatment with nitrogen mustard and prednisone, a hemiplegia and facial hemiparesis disappeared, as did splenomegaly and lymphadenopathy. The amounts of macro-globulins in the serum decreased from 5.9 to 3.7 g/100 ml. Addition of mercaptoethanol to the serum resulted in the depolymerization of the macroglobulin molecule to 6 monomers of the size of gamma globulin. It appears that the macroglobulins are polymers of a protein unit of the same molecular dimensions as those of normal gamma globulin, and that the polymer cross linkage involved in their formation is of the nature of a sulfur-sulfur (cystine) bond.Keywords
This publication has 2 references indexed in Scilit:
- MACROGLOBULINEMIA OF WALDENSTRÖM: A REVIEW OF THE LITERATURE AND PRESENTATION OF A CASEAnnals of Internal Medicine, 1956
- RECURRENT PNEUMONIA IN MULTIPLE MYELOMA AND SOME OBSERVATIONS ON IMMUNOLOGIC RESPONSEAnnals of Internal Medicine, 1954