Correlation between serum concentration and pharmacological effect on atrioventricular conduction time of the antiarrhythmic drug propafenone

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Abstract
Summary Seven patients with cardiac dysrhythmias received a single, oral, therapeutically effective dose of the antiarrhythmic drug propafenone. The serum levels correlated well with changes in atrioventricular conduction times during the postabsorptive elimination phase (r=0.6810, p<0.001). The mean half-lives of the serum level and the electrocardiographic effect (PQ-time) were 3.6±0.2 h and 3.8±0.6 h, respectively.