Blausäurebildung als Fehlerquelle bei der Chloridbestimmung nach van Slyke

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Abstract
It was found that under conditions of the van Slyke chloride estimation (heating the sample with 65% HNO3 in the presence of AgNO3, and back titration of the Ag) cyanide is formed, which, combining with Ag, leads to considerable errors when the chloride concentration is low. Cyanide formation was demonstrated both qualitatively in the Ag residues, and quantitatively by heating the substances in the presence of the usual concentration of nitric acid, but aerating the cyanide formed into an ammonia solution. It was found that the only 2 amino acids yielding cyanide were tyrosine and tryptophan, and that the amount of cyanide formed during the treatment of proteins was dependent entirely on the content of these 2 amino acids.

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