Formation of Prothrombin Derivatives From Purified Prothrombin
- 28 February 1951
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 164 (3) , 722-726
- https://doi.org/10.1152/ajplegacy.1951.164.3.722
Abstract
Two derivatives of purified prothrombin were obtained. Both are refractory to the action of Ca plus thromboplastin plus Ac-globulin. One forms when purified prothrombin is dissolved in 25% Na citrate soln. plus 3,4,4[image]-triaminodiphenyl sulfone. The other forms when 3-chloro-4,4[image]-diaminodiphenyl sulfone is used in conjunction with the 25% Na citrate soln. The latter derivative eventually becomes transformed into thrombin, and probably represents an intermediate in the process of thrombin formation. It is suggested as a possibility that this intermediate always forms when prothrombin becomes activated.Keywords
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