Interference between Polyoma and Vesicular Stomatitis Viruses in Tissue Culture

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Abstract
Summary: Following infection with polyoma virus cultures of mouse embryo cells acquire resistance to the virus of vesicular stomatitis just before or at the time hemagglutinins become detectable but well in advance of cytopathic effects. Propagation of the challenge virus may be completely prevented but the polyoma virus is not affected by the superinfection. Interference with VSV is established in from 2 days to more than 10 days depending upon the dose of polyoma virus initially inoculated.

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