Disruption of the Metabolism, Motility and Morphology of Spermatozoa by Injection of a-Chlorohydrin Into Rams

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Abstract
Ejaculated spermatozoa from rams given i.m. injections of .alpha.-chlorohydrin (25 mg/kg, daily for 5 days) were studied. Respiratory and glycolytic activity of the spermatozoa was almost entirely suppressed within 1 day an motility had decreased within 4 days of the 1st injection. Morphologically abnormal spermatozoa appeared in ejaculates after 2 wk. The most common abnormality was an increase in the number of spermatozoa with looped or bent tails. There was little change in the fructose or amino acid concentration of the seminal plasma. All effects of .alpha.-chlorohydrin were fully reversible. The initial primary mode of action of .alpha.-chlorohydrin may be to disrupt the metabolism of spermatozoa in the cauda epididymis.

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