The Suppressor-Cell Network in Cancer

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Abstract
(First of Two Parts)IN the near future, new insights into the cellular control of immune reactivity may become important to physicians who manage patients with cancer. The objectives of this article are to provide an overview of the suppressor-cell system that regulates normal immune responses, to summarize the role of suppressor cells in the immunologic enhancement of malignant neoplasms, to categorize the alterations of suppressor-cell activity that may cause, or at least perpetuate, the immunodeficiency state that occurs in certain patients with cancer, and to discuss the implications of suppressor-cell function in devising new immunologic strategies for the therapy . . .

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