Concentrations of thiopentone in mature breast milk and colostrum following an induction dose

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Abstract
In two groups of eight patients, concentrations of thiopentone in mature breast milk and colostrum following anaesthesia induction with 5.4 and 5.0 mg kg-1 b.w. (mean), respectively, were measured in the first 36 h postoperatively. Blood concentrations were measured simultaneously. The maximal concentrations were; in mature breast milk, 3.4 .+-. 0.68 .mu.mol l-1 (mean .+-. s.e. mean) (0.090 mg 100 ml-1), and in colostrum, 1.3 .+-. 0.5 .mu.mol l-1 (0.034 mg 100 ml-1). The milk/plasma ratio was < 1.0 in both groups. The above concentrations may be regarded as negligible and therefore non-toxic for the nursing infant.

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