ACTH Therapy for Infantile Spasms: A Combination Therapy with High-Dose Pyridoxal Phosphate and Low-Dose ACTH
Open Access
- 1 May 1998
- Vol. 39 (S5) , 42-45
- https://doi.org/10.1111/j.1528-1157.1998.tb05149.x
Abstract
Summary: Combination therapy consisting of high‐dose pyridoxal phosphate (40–50 m/kg/day) and low‐dose synthetic ACTH (0.01 mg/kg/day) was prescribed in 28 children with infantile spasms. Monotherapy with pyridoxal phosphate provided excellent seizure control in 3 of the 28 (11%) patients. ACTH was subsequently added to the regimen of the remaining 25 patients. As of 1 month after discontinuing the ACTH treatment, 21 of the 25 (84%) patients had experienced no seizures. The mean interval until seizure control was achieved was 4.1 days after the start of treatment with ACTH. The 21 patients have been monitored for a mean of 34.9 months (range 2–81 months); 6 patients (29%) have had recurrences of infantile spasms, and 10 (48%) have experienced normal development. Fourteen of the 28 patients (50%) have had transient increases in liver enzymes, but none of the patients developed more serious side effects.Keywords
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