Inhibitory Effect of Ammonium Ions on Influenza Virus in Tissue Culture

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Abstract
Ammonium ions in trace amounts were shown to exert a very marked protective effect upon a tissue culture system infected with influenza virus. The ions inhibited viral synthesis as well as viral CPE and the effect was apparently not due to interference with virus adsorption or to a direct inactivation of the virus. It was also shown that the tissue culture system produced sufficient ammonia during growth to render itself insusceptible to the virus.