Clinical studies on cell-mediated immunity in patients with renal cell carcinoma: interleukin-2 and interferon-γ production of lymphocytes

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Abstract
The authors examined interleukin-2 (IL-2) production and interferon γ (IFNγ) production of peripheral blood mononuclear cells in 28 patients with renal cell carcinoma and 17 control subjects. The peripheral blood was obtained prior to the initiation of therapeutic procedures. The patients were divided into two groups according to tumor size, ⩽5 cm and >5 cm. The production of IL-2 and IFNγ was measured by immunoradiometric assay. As a result, in the patients with tumors >5 cm, IL-2 and IFNγ production was impaired. However, in the patients with tumors ⩽5 cm, IFNγ production was enhanced, though IL-2 production was not significantly different from that of the control subjects. There was no significant correlation between IL-2 production and IFNγ production.

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