Ni-Gehalt in der Milch laktierender Ratten bei unterschiedlicher Ni-Versorgung

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Abstract
Model experiments were carried out with rats showing that the average Ni concentrations in the milk of the experimental animals receiving a Ni deficient diet (40 ppb of dietary Ni), relative to those of the controls (20 ppm), declined from 1088 ng/g to 726 ng/g (33%). This produced a Ni deficiency in the youngs of the rats resulting in retarded growth, reduced Fe absorption and a decline in enzymatic activity. An increase in the Ni content of the milk from both the experimental animals and the controls was observed during lactation. In the Ni deficient group this upward trend was longer noticeable from about the middle of the lactation period onwards. Animals in the Ni deficient group excreted about three times as much Ni through the milk as was ingested with the food. Because of the wide range of deviations of the Ni content in the different animals the Ni content of the milk cannot be used, under practical conditions, as an index of a state of Ni deficiency.

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