Diphosphonate Treatment in Bone Disease

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Abstract
Great progress has been achieved in the last two decades in bone and calcium physiology. Understanding of collagen, proteoglycan and apatite structure and of calcium metabolism has improved a great deal. Two new hormones, calcitonin and 1,25-dihydroxycholecalciferol, have been discovered. Despite all these developments, the treatment of most of the diseases involving calcium is little changed from that of 20 years ago. A number of diverse therapeutic agents have been tried with varying success. The latest newcomers are the diphosphonates, and in this issue of the Journal, Altman et al. describe the use of disodium ethane-1-hydroxy-1,1-diphosphonate (EHDP) in Paget's . . .