EXPERIMENTAL GASTROJEJUNAL ULCERS DUE TO ANTRUM HYPERFUNCTION

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Abstract
IN PREVIOUS studies from this laboratory, the antrum of the stomach in dogs was found to be the sole source of the gastric secretory excitant, gastrin, and to function as an endocrine organ. When quantitative collections of gastric juice were made in Heidenhain pouch dogs, removal of the antrum was found to reduce the secretion of gastric juice by an average of 86%.1 A similar marked reduction in secretion from the Pavlov pouch was produced when the antrum was removed from its normal location and converted into a closed pouch and its secretions drained to the exterior by means of a cannula. When this antrum pouch was subsequently transplanted into the wall of the duodenum as a diverticulum so that it could come in contact with food, the secretion from the fundus pouch was restored to the normal level. When, however, the antrum pouch was transplanted into the wall

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