Monoamine Levels and Choline Acetylase Activity in Brain and Effect of Reserpine and Dihydroxyphenylalanine after Cerebral Lesions

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Abstract
Bilateral ablation of the cerebral cortex or the nucleus caudatus in rabbits did not alter the reaction to administration of reserpine. The effect of the latter was completely inhibited by injection of dihydroxyphenylalanine (DOPA). A reduced reserpine effect was observed in thalamectomized animals. Administration of DOPA to these animals produced great excitation. Neither cortical ablation nor thalamectomy altered the choline acetylase activity in the caudate nucleus.