Sister chromatid exchanges and heterochromatin
- 1 April 1981
- journal article
- Published by Springer Nature in Human Genetics
- Vol. 57 (2) , 119-130
- https://doi.org/10.1007/bf00282006
Abstract
The inter- and intrachromosomal distribution patterns of SCEs obtained with or without mutagen treatment are reviewed and compared, with each other as to their relation to heterochromatin and with the distribution patterns of chromatid aberrations that occurred either “spontaneously” in chromosomes of repair-defective human syndromes or after treatment with the mutagens (BrdU, ethylalcohol, DMBA, TMBA, maleic hydrazide, MMS, MMC). The conclusions are: No general rule is detectable for nonrandom involvement of heterochromatin in spontaneous SCEs. Mutagen-induced SCEs show the same or very similar distribution patterns as the spontaneous ones and are in no case as preferentially located as chromatid aberrations (which involve mainly the junctions between eu- and heterochromatin or other special regions). Therefore, a specific mutagen sensitivity of heterochromatincontaining chromosome regions as observed for chromatid aberrations does not exist (or is less pronounced) for SCEs. This supports the inference that different mechanisms underlie the origins of the two phenomena.Keywords
This publication has 50 references indexed in Scilit:
- Heterochromatin and sister chromatid exchanges in the chromosomes of Microtus agrestisHereditas, 2009
- Use of the 5-bromodeoxyuridine-labelling technique for exploring mechanisms involved in the formation of chromosomal aberrationsMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1980
- Sister chromatid exchanges in barleyTheoretical and Applied Genetics, 1980
- Detection of sister chromatid exchanges in vivo in somatic cells of Drosophilia melanogasterMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1979
- BrdU-Giemsa-technique for the differentiation of sister chromatids in somatic cells of Drosophila melanogasterMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1977
- Localization of chromatid breaks in Fanconi's anemia, using three consecutive stainsHuman Genetics, 1977
- Sister chromatid exchanges in balanced translocation carriers and in patients with unbalanced karyotypesHuman Genetics, 1977
- Mapping of sister-chromatid exchanges in human chromosomes using G-banding and autoradiographyMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1976
- Analysis of the frequency of sister chromatid exchange in different regions of chromosomes of the kangaroo rat (Dipodomys ordii)Chromosoma, 1976
- Sister chromatid exchanges and chromatid interchanges in Bloom's syndromeHuman Genetics, 1975