STUDIES ON STAPHYLOCOCCI III

Abstract
A water soluble globulin fraction from normal human serum was shown to have a direct lethal and lytic action on Staphylococcus aureus when used in sufficient concentration. The activity of the fraction could be demonstrated only when the cells were exposed in an aqueous suspension or in buffers below 10-4 [image] The antibacterial factor was stable to heating at 70[degree] C for 30 minutes, and its activity was the same over a pH range from 6 to 9. A substance of similar activity was demonstrated in rabbit and horse serum, but not in bovine serum. The serum globulin fraction also inhibits the oxidation of glucose by Bacillus subtilis and Micrococcus lysodeikticus. The anti-bacterial activity of the fraction could be reversed by treating staphylo-cocci or B. subtilis with coagulase. M. lysodeikticus could not be thus protected.

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