Section Review Biologicals & Immunologicals: Advances in antibody engineering

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Abstract
Our ability to genetically modify antibody molecules has been dramatically enhanced by a number of technological breakthroughs, including the ability to rapidly and easily clone the variable region genes, and the development of good expression systems. In addition phage display technology has given a new impetus to the field by allowing the isolation and modification of novel antibodies. This paper reviews these important areas, and describes some of the more common genetic constructs that have been produced. Such recombinant molecules are entering clinical trials more frequently and will become increasingly important as diagnostic and therapeutic agents.