DEPENDENCE OF RATIO OF RADIOIODIDE CONCENTRATIONS IN THYROID GLAND AND SERUM ON SERUM IODIDE CONCENTRATION: WITHOUT PROPYLTHIOURACIL

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Abstract
The dependence of the ratio of the thyroid radioiodide concentration to the serum radioiodide concentration (T/S ratio) on the serum iodide concentration was studied in male C3H mice. On increasing the serum iodide concentration, starting at low levels, the T/S ratio remained constant until the binding of radioiodide began to be blocked. The T/S ratio then increased with the serum iodide concentration until the amount of iodide bound was small compared with the thyroid iodide content. As the serum iodide concentration was further increased, the T/S ratio progressively decreased. When binding was blocked by propylthiouracll and iodide the T/S ratio was approximately twice that when binding was blocked by iodide alone.