Bapx1 regulates patterning in the middle ear: altered regulatory role in the transition from the proximal jaw during vertebrate evolution
Open Access
- 15 March 2004
- journal article
- Published by The Company of Biologists in Development
- Vol. 131 (6) , 1235-1245
- https://doi.org/10.1242/dev.01017
Abstract
The middle ear apparatus is composed of three endochondrial ossicles (the stapes, incus and malleus) and two membranous bones, the tympanic ring and the gonium, which act as structural components to anchor the ossicles to the skull. Except for the stapes, these skeletal elements are unique to mammals and are derived from the first and second branchial arches. We show that, in combination with goosecoid (Gsc), the Bapx1 gene defines the structural components of the murine middle ear.Keywords
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