ANALOG-COMPUTER MONITORING AND EVALUATION OF A DOSING NOMOGRAM FOR GENTAMICIN BASED ON THE C'MIN-METHOD .1.

  • 1 January 1980
    • journal article
    • research article
    • Vol. 18  (10) , 425-430
Abstract
Present methods for dosing the antibiotic gentamicin are based on usual doses or desired peak concentrations. The effective range is 3-10 .mu.g/ml. A method is proposed to maintain the minimum steady-state concentration at a desired MIC [minimum inhibitory concentration], with peak concentrations not exceeding 10 .mu.g/ml. After determination of the log serum creatinine-log creatinine clearance relationship in a specific population group (Peruvian mestizos), a nomogram for dosing gentamicin was developed. The applicability of the nomogram or the corresponding equation upon which the nomogram was based was tested in patients for desired MIC of 0.5, 1.0, 1.5 and 2.0 .mu.g/ml, and the actual c''min [minimum blood concentration] values obtained were compared with predicted levels. Using a correction factor, the nomogram is applicable for the USA and European populations. The importance of drug level monitoring is emphasized.

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