Serum Prostatic Acid Phosphatase and Cancer of the Prostate

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Abstract
THE acid phosphatase content of malignant prostatic tissue is regarded as an example of the retention by the neoplastic growth of a biochemical characteristic of the fully differentiated tissue of origin. For fifteen years the serum acid phosphatase determination has been accepted as an adjuvant method for the diagnosis of cancer of the prostate. The findings of elevated values have been correlated with advanced cancer of the prostate with spread to bones and rarely with nonmetastatic disease. As a consequence, the finding of an elevated serum acid phosphatase in a patient with clinical evidence of localized cancer of the prostate . . .