Brefeldin A and filipin distinguish two globotriaosyl ceramide/verotoxin-1 intracellular trafficking pathways involved in Vero cell cytotoxicity
- 24 March 2004
- journal article
- research article
- Published by Oxford University Press (OUP) in Glycobiology
- Vol. 14 (8) , 701-712
- https://doi.org/10.1093/glycob/cwh085
Abstract
In verotoxin 1 (VT1)-sensitive cells, globotriaosyl ceramide (Gb3) bound VT1 is endocytosed and transported retrogradely to the Golgi/endoplasmic reticulum (ER). The importance of the Golgi-dependent retrograde transport of VT1 is now shown to vary as a function of both VT1 exposure time and concentration. Following 3 h exposure to 3.Keywords
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