Anti-Ku Antibody-Positive Scleroderma-Dermatomyositis Overlap Syndrome Developing Graves' Disease and Immune Thrombocytopenic Purpura.
- 1 January 2002
- journal article
- case report
- Published by Japanese Society of Internal Medicine in Internal Medicine
- Vol. 41 (12) , 1199-1203
- https://doi.org/10.2169/internalmedicine.41.1199
Abstract
Graves' disease (GD) has been reported to be frequently complicated with other autoimmune diseases. However, it is rarely complicated with scleroderma-polymyositis overlap syndrome. Recently, we encountered a 35-year-old woman who developed GD and immune thrombocytopenic purpura during follow-up observation of scleroderma-dermatomyositis overlap syndrome. Platelet counts recovered after high-dose gamma-globulin therapy and bolus methylprednisolone therapy. The present case is the first report of a combination of scleroderma, dermatomyositis, GD, and immune thrombocytopenic purpura. The patient was anti-Ku antibody-positive and had relatively low natural killer T cell counts, both of which might contribute to the complication of multiple autoimmune diseases.Keywords
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