The pharmacokinetics of porcine glucose‐dependent insulinotropic polypeptide (GIP) in man

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Abstract
The pharmacokinetics of porcine glucose‐dependent insulinotropic polypeptide were investigated in six healthy volunteers. At the maximum infusion dose (0·5 pmol kg‐1 min‐1) a plateau concentration of 115 ± 5·0 pmol/l plasma was obtained. On discontinuation of the infusion, the half‐time of disappearance was calculated to be 20·3 ± 1·2 min. The metabolic clearance rate was 2·6 ± 0·1 ml kg‐1 min‐1 and the apparent space of distribution was 75·8 ± 5·7 ml kg‐1. Blood glucose, pancreatic and gastrointestinal hormones remained at basal concentrations throughout. No side effects were noted by any of the subjects studied.