Immunoperoxidase localization of secretory component in reactive mesothelium and mesotheliomas.
Open Access
- 1 September 1981
- journal article
- research article
- Published by SAGE Publications in Journal of Histochemistry & Cytochemistry
- Vol. 29 (9) , 1102-1104
- https://doi.org/10.1177/29.9.7026669
Abstract
Immunoperoxidase localization of the secretory component (SC) of immunoglobulin (Ig) A was undertaken on paraffin-embedded tissue to investigate its usefulness in differentiating epithelial from mesothelial neoplasms. Epithelial cells, but not mesothelial cells, have been previously reported to contain SC, which may be involved in the intraepithelial transport of secretory IgA. In this study we report, for the first time, focal but unequivocal staining for SC in reactive mesothelium and mesotheliomas (10/16). Reactivity was not associated with any histologic subtype of malignant mesothelioma although staining was usually seen in the "epithelial" type. The significance in terms of possible mesothelial secretory IgA transport is discussed.This publication has 6 references indexed in Scilit:
- Absence of carcinoembryonic antigen-like material in mesotheliomaAn immunohistochemical differentiation from other lung cancersCancer, 1979
- Study of immunoglobulins in pleura and pleural effusions.Thorax, 1979
- Immunodiagnosis of mesothelioma. Use of antimesothelial cell serum in an indirect immunofluorescence assayCancer, 1979
- Immunoglobulins and secretory component in endometrium and cervixVirchows Archiv, 1978
- STUDIES ON TRANSLOCATION OF IMMUNOGLOBULINS ACROSS INTESTINAL EPITHELIUM .2. IMMUNOELECTRON-MICROSCOPIC LOCALIZATION OF IMMUNOGLOBULINS AND SECRETORY COMPONENT IN HUMAN INTESTINAL-MUCOSA1976
- THF EARLY STAGES OF ABSORPTION OF INJECTED HORSERADISH PEROXIDASE IN THE PROXIMAL TUBULES OF MOUSE KIDNEY: ULTRASTRUCTURAL CYTOCHEMISTRY BY A NEW TECHNIQUEJournal of Histochemistry & Cytochemistry, 1966