Pigment Mosaics in Irradiated Human Skin: a New Test of Cellular Survival Curve Theory

Publisher Website
Google Scholar
Abstract
The appearance, at the site of healed desquamative skin reactions in pigmented subjects, of visible, irregularly pigmented domains, presumably consisting of clones derived from individual surviving cells, suggests a possible approach to testing cell survival curve models for normal tissues irradiated in vivo. The mean cellular lethal dose, the extrapolation number, and the mean generation time for cells proliferating in the intervals between fractions may be estimated from the size and density of the pigmented domains observed in patients receiving various conventionally fractionated radiation therapy routines.

This publication has 1 reference indexed in Scilit: