CD4+8− help prevents rapid deletion of CD8+ cells after a transient response to antigen
- 1 August 1993
- journal article
- Published by Wiley in European Journal of Immunology
- Vol. 23 (8) , 1963-1967
- https://doi.org/10.1002/eji.1830230835
Abstract
We have followed the fate of mature CD8+ T cells with a male‐specific transgenic T cell receptor after antigenic stimulation with hemopoietic cells in the absence or presence of help. Our data show that mature CD8+ T cells can be deleted after a 3‐week period of transient activation and that help, e.g. in the form of interleukin‐2, can considerably delay the deletion. These experiments have implications for the design of protocols aiming at the establishment of specific immunological tolerance in T cells.Keywords
This publication has 25 references indexed in Scilit:
- Environmental modulation of the autonomy of cytotoxic T lymphocytesEuropean Journal of Immunology, 1993
- A fail-safe mechanism for maintaining self-tolerance.The Journal of Experimental Medicine, 1992
- Peripheral tolerance through clonal deletion of mature CD4−CD8+ T cellsInternational Immunology, 1992
- Exclusion and inclusion of α and β T cell receptor allelesCell, 1992
- Roles of alphabeta and gammadelta T Cell Subsets in Viral ImmunityAnnual Review of Immunology, 1992
- Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic miceCell, 1991
- Peripheral Selection of the T Cell RepertoireScience, 1991
- Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules.The Journal of Experimental Medicine, 1989
- Properties of purified T cell subsets. I. In vitro responses to class I vs. class II H-2 alloantigens.The Journal of Experimental Medicine, 1985
- Autonomously proliferating K/D‐restricted cytolytic T cell clonesEuropean Journal of Immunology, 1983