Cali-Harvard Nutrition Project

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Abstract
Studies on the daily requirements of folic acid for the remission of megaloblastic dysplasia seen in malnourished children (kwashiorkor and marasmus) were carried out. Folic acid, 20 µg. per day given orally (in some cases less), caused a remission in the megaloblastic bone marrow. The value of sideroblast counts in diagnosing bone marrow changes associated with the oral administration of folic acid is discussed. The changes in serum electrolytes, protein, protein fractions and cholesterol with protein feeding is presented.