Fragile sites and chromosome breakpoints in constitutional rearrangements II. Spontaneous abortions, stillbirths and newborns
- 1 September 1984
- journal article
- research article
- Published by Wiley in Clinical Genetics
- Vol. 26 (3) , 174-177
- https://doi.org/10.1111/j.1399-0004.1984.tb04364.x
Abstract
Certain fragile sites may possibly predispose to [human] chromosome breakage and rearrangements in meiosis. To test this hypothesis, 894 breakpoints found in spontaneous abortions, stillbirths and livebirths were examined of which 165 (18.5%) were in bands with fragile sites. Compared to an expectation of 98 (11%), there was a significant excess of breakpoints in fragile site bands (P < 0.001). Together with data from amniocenteses, there is now evidence suggesting that certain fragile sites may be prone to fragility in meiosis.Keywords
This publication has 1 reference indexed in Scilit:
- Fragile sites and cancer breakpointsCancer Genetics and Cytogenetics, 1984