Secretion of γ‐Interferon at the Cellular Level

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Abstract
Using a hemolytic plaque assay for .gamma.-interferon (IFN-.gamma.) secretion it was found that in vitro Epstein-Barr virus (EBV) exposure of peripheral blood mononuclear cells from EBV immune individuals led to IFN-.gamma. secretion, which was apparent within 6 h after virus contact and peaked 12-24 h after induction. Live, UV-light-irradiated and heat-inactivated virions all caused IFN-.gamma. secretion. Blood mononuclear cells from EBV non-immune adults or neonates could not be activated to IFN-.gamma. production by EBV.